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Mission Statement

The Cardiovascular Research Network (CVRN) aims to provide a systematic understanding of the epidemiology of cardiovascular disease; its diagnosis and management; and robust data on cardiovascular-related clinical outcomes, resource utilization and costs.


CVRN Objectives

  • Provide more robust cardiovascular disease and related health care surveillance data than currently available
  • Promote research on clinical practice and quality of care
  • Enable assessment of new diagnostic and therapeutic technologies and clinical guidelines on cardiovascular disease and risk factor incidence, prevalence, clinical management, and patient outcomes over time
  • Facilitate and promote research on determinants of disease for uncommon disease phenotypes
  • Create opportunities for interested non-network researchers to collaborate with CVRN investigators on high-priority cardiovascular issues.


Center Locations

There are 11 participating CVRN centers, with over 10 million health plan members, comprised of a health care delivery system and a corresponding dedicated research entity:

         1. Fallon Community Health Plan

          2. HealthPartners

          3. Henry Ford Health System

          4. Kaiser Permanente Colorado

          5. Kaiser Permanente Georgia

          6. Kaiser Permanente Northern California

          7. Kaiser Permanente Northwest

          8. Kaiser Permanente Southern California

          9. Kaiser Permanente Washington

          10. Marshfield Clinic

          11. Scott and White Health Plan





Data Resources

​The VDW is a cornerstone of CVRN collaboration. The CVRN’s Virtual Data Warehouse (VDW) facilitates multi-site research while protecting patient privacy and proprietary health practice information. CVRN organizations agree on data to make available for research and derive standard definitions and formats – but each CVRN member organization maintains control of its own data via a “distributed” or “federated” model. Administrative, clinical and claims data are translated to a common set of data standards at each site.

How Researchers Use the VDW:

          1.  Work with collaborators to develop the study protocol.

          2. Obtain relevant regulatory, contractual and ethical approvals.

          3. A SAS analytic program is developed at the lead study site.

          4. The project sites run the program against their local VDW and return project-specific datasets (often aggregate)                to the lead site for data pooling. This process may be reiterative, depending on the complexity and availability of                  the data within the VDW.



Frequently Asked Questions
  1. What is the CVRN?
  2. How many centers make up the CVRN?
  3. What services and opportunities does the CVRN offer to researchers?
  4. I am interested in working with the CVRN, but am new to research. How do I begin collaboration?
  5. What is the difference between a Manuscript Analysis Request, a Grant Preliminary Analysis Request, a Manuscript Draft for Review, and a Grant Proposal?
  6. Does the CVRN charge for endorsement of manuscripts or grant proposals?
  7. What are the CVRN datasets?
  8. What is the purpose of the CVRN datasets?
  9. How do I know which dataset to use?
  10. Where can I find more information on CVRN datasets?
  11. I have a new idea for cardiovascular research (which existing datasets do not cover); can I still use the CVRN services offered?

  1. What is the CVRN?

The Cardiovascular Research Network (CVRN) is a national research consortium and resource that leverages research expertise, populations, and data sources from 11 geographically diverse health care delivery systems (10 million members) in the United States.

  1. How many centers make up the CVRN?

There are currently 11 CVRN centers comprised of a health care delivery system and a corresponding dedicated research entity.

CVRN Organization

   Research Entity & Location

   Kaiser Permanente Northern California *CVRN Lead Organization  

  Division of Research
  Oakland, CA

   Fallon Community Health Plan

  Meyers Primary Care Institute
  Worcester, MA

   Kaiser Permanente Washington

  Health Research Institute
  Seattle, WA

   HealthPartners

  HealthPartners Research Foundation
  Minneapolis, MN

   Henry Ford Health System

  Center for Health Services Research
  Detroit, MI

   Kaiser Permanente Colorado

  Institute for Health Research
  Denver, CO

   Kaiser Permanente Northwest

  Center for Health Research
  Portland, OR

   Kaiser Permanente Georgia

  Center for Clinical & Outcomes Research
  Atlanta, GA

   Kaiser Permanente Southern California

  Department of Research & Evaluation
  Pasadena, CA

   Marshfield Clinic

  Marshfield Clinic Research Foundation
  Marshfield, WI

   Baylor Scott and White

  Division of Research & Education
  Temple, TX

  1. What services and opportunities does the CVRN offer to researchers?
  • The CVRN offers opportunities for researchers from any institution to collaborate on multi-institutional, cardiovascular research projects by partnering with CVRN researchers to leverage robust health care-related clinical and administrative data--most of which is accessible electronically--derived from large, diverse community-based populations.

  • The CVRN will provide letters of support/endorsement for grant proposals that include CVRN collaborators and align with CVRN goals.

  • The CVRN offers a number of existing research datasets for collaboration on new cardiovascular research ideas or manuscripts. Researchers from any institution are able to suggest new grant proposals and/or manuscript analyses based on large, research-quality datasets from completed or ongoing CVRN projects using each contributing center's Virtual Data Warehouse (VDW).

  • The CVRN will review manuscript ideas and, if approved, provide analytic support  options as follows:

    1. Working directly with the lead investigator to complete analyses and report results in a timely manner

    2. Providing a scrambled, de-identified analytic dataset which will allow them to test SAS code for approved descriptive and multivariable analyses that are then run on the source analytic dataset to generate the study results.


  1. I am interested in working with the CVRN, but am new to research. How do I begin collaboration?
  • If you are looking to collaborate on existing data for the purpose of writing new manuscripts, please go to the Projects page to learn about the CVRN datasets currently available for collaboration.  You may reach out to any of the people listed in the ‘Contacts and Other Resources’ section of each dataset description.
  • If you are looking to conduct a new study, please see the Collaborations page

  1. What is the difference between a Manuscript Analysis Request, a Grant Preliminary Analysis Request, a Manuscript Draft for Review, and a Grant Proposal?
  • Manuscript Analysis Request:  This is when you have a request for proposing a data analysis based on EXISTING completed CVRN project datasets.  The results of an approved Manuscript Analysis Request will be used to develop a manuscript to submit for publication in a peer-reviewed journal.
  • Grant Preliminary Analysis Request: This is when you have a request for feasibility analysis on EXISTING CVRN datasets when considering a new CVRN grant proposal idea.  The results of an approved request in this situation will be used to develop a collaborative CVRN grant proposal.
  • Manuscript Draft for Review:  This occurs when you have a manuscript which includes a CVRN-related study or data sponsored by the CVRN that you are about to submit to a journal for publication consideration.  It is mandatory that you submit your manuscript draft to the CVRN New Proposals and Publications Committee for rapid review and to ensure that the funding agency is properly acknowledged before submission.
  • Grant Proposal: This is when you have a new collaborative CVRN grant proposal for a study you plan to submit to a funder.  The proposal includes collaborating with a CVRN site and CVRN data.  You are submitting a grant proposal request so that you can obtain CVRN endorsement of this proposal before you submit to the funder.

  1. Does the CVRN charge for endorsement of manuscripts or grant proposals?

No, endorsement of approved CVRN manuscripts and grant proposals is free of charge.

  1. What are the CVRN datasets?

Each research dataset is generated from an existing CVRN multi-site project and includes longitudinal clinical and administrative information derived from the CVRN Virtual Data Warehouse (VDW) as well as other data sources. In each dataset description provided on www.cvrn.org, you will find systematic information on the cohort assembly process (including inclusion and exclusion criteria as well as data sources), cohort characteristics, key exposure and outcome variables, existing scientific abstracts and publications, and the corresponding CVRN contacts and resources. Certain dataset descriptions may also contain additional information, such as more specific details about dataset creation processes as well as important analytic considerations.

  1. What is the purpose of the CVRN datasets?

The CVRN Datasets allow collaborators to suggest new grant proposals and/or manuscript analyses based on large, research quality datasets from completed or ongoing CVRN projects.

  1. How do I know which dataset to use?

Descriptions of each dataset are available through each Project Page. These descriptions provide information on dataset population, cohort characteristics, cohort inclusion and exclusion criteria, dataset creation steps, variables, important analytic considerations, existing scientific abstracts and publications, and corresponding CVRN contacts. Such descriptions are available to aid collaborators in determining if a dataset aligns with their aims.

  1. Where can I find more information on CVRN datasets?

Descriptions of each dataset are available at http://cvrn.org/collaboration/datasets.aspx. These descriptions provide information on dataset population, cohort characteristics, cohort inclusion and exclusion criteria, dataset creation steps, variables, important analytic considerations, existing scientific abstracts and publications, and corresponding CVRN contacts. Such descriptions are available to aid collaborators in determining if a dataset aligns with their aims.

  1. I have a new idea for cardiovascular research (which existing datasets do not cover); can I still use the CVRN services offered?

Absolutely. Please see the Collaborations page of the site. You may also contact the CVRN Director, Dr. Alan S. Go (alan.s.go@kp.org), or Sue Hee Sung (sue.hee.sung@kp.org) for more information.