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Multiple Chronic Conditions, Frailty, and Mobility/Functional Impairment
in Older Adults with Heart Failure (MCC-HF) Study
Atria Project

Leadership:

Alan S. Go, MD, Investigator Kaiser Permanente Northern California
Heather Allore, PhD, Investigator University of Massachusetts Medical School
Jerry Gurwitz, MD, Investigator Meyers Primary Care Institute
Mayra Tisminetzky, MD, PhD, Investigator University of Massachusetts Medical School
Robert Goldberg, PhD, Investigator University of Massachusetts Medical School
Terrence Murphy, PhD, Investigator University of Massachusetts Medical School

Study Summary

The CVRN MCC-HF dataset is comprised of patients with diagnosed heart failure (HF) and had an assessment of left ventricular systolic function within ±2 years of HF diagnosis date. Patients were included in the MCC-HF cohort between January 1, 2005 through December 31, 2012. MCC-HF members were further stratified by co-morbid conditions using ICD-9 diagnosis codes. The MCC-HF dataset is comprised of patient data from five participating health plans: Kaiser Permanente Northern California, Kaiser Permanente Colorado, Kaiser Permanente Northwest, Kaiser Permanente Southern California, and Fallon Health-Reliant Medical Group. The Dataset was comprised using standardized programs that convert local source data-extract into a common dataset structure with the same mapped variables.


Population

The MCC-HF dataset is comprised of patients with diagnoses HF and with an assessment of left ventricular systolic function. Diagnosed HF is defined as:

  • 1 primary discharge diagnosis of HF, or
  • 3  ambulatory visits coded for HF with at least one visit being to a cardiologist during the study period.

A total of 114,553 members were included in the cohort. The mean age of HF diagnosis was 73.3 years and 45.9% were women.


Figure 1. MCC-HF Study Dataset Age Distribution



Cohort Characteristics


Figure 2. Distribution of Comorbidities in MCC-HF Dataset




Data Source

All member data was extracted using the Virtual Data Warehouse (VDW). The VDW is a standardized resource comprised of: (1) computerized datasets stored behind separate security firewalls, including variables with identical names, formats, and specifications; (2) informatics tools that facilitate storage, retrieval, processing, and managing the datasets; and (3) detailed data documentation. All data are linked by a unique identifier so that data elements can be rolled up to the individual person-level. 


Key Publications

Gurwitz, J. H., Magid, D. J., Smith, D. H., Tabada, G. H., Sung, S. H., Allen, L. A., ... & Go, A. S. (2017). Treatment effectiveness in heart failure with comorbidity: lung disease and kidney disease. Journal of the American Geriatrics Society65(12), 2610-2618.

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