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Anticoagulation Treatment and Long-Term Outcomes After Venous Thromboembolism

(CVRN VTE) Study

Atria Project

Leadership:

Alan S. Go, MD, Investigator Kaiser Permanente Northern California
Daniel M. Witt, PharmD, FCCP, BCPS, CACP, Investigator Kaiser Permanente Colorado
Margaret C. Fang, MD, MPH, Investigator University of California, San Francisco
Nirav R. Shah, MD, MPH, Investigator Geisinger Health System
Stephen Yale, MD, Investigator Marshfield Clinic Research Foundation

Study Summary

The CVRN VTE dataset consists of patients with a venous thromboembolism (VTE) event between January 1, 2004 through December 31, 2007 with follow-up through 2013. The CVRN VTE dataset has been used to identify clinical predictors and clinical risk schemes to predict recurrent VTE and major hemorrhage after an initial VTE event. The CVRN VTE dataset utilizes patient data from four diverse health plans. The dataset was compiled using standardized programs that convert local source data extract into a common dataset structure with the same mapped variables and corresponding definitions.


Population


Table 1. CVRN VTE Dataset Member Counts by Site


​Site
Number of Members
​Percent of Dataset
Kaiser Permanente Northern California​
​3,238
58.9%​
Kaiser Permanente Colorado​
​1,336
24.3%​
Geisinger Health System​
520​
9.5%​
Marshfield Clinic Research Foundation​ 403​
7.3%
Total​ 5,497​
100.0%​


Cohort Characteristics

The CVRN VTE cohort consist of adults aged 18 years or older at the time of VTE event. The mean age of VTE event was 65.7 years and 51.4% were women.


Figure 1. Distribution of Race for Members in the CVRN VTE Dataset



Data Source

All member data was extracted using the Virtual Data Warehouse (VDW). The VDW is a standardized resource comprised of: (1) computerized datasets stored behind separate security firewalls, including variables with identical names, formats, and specifications; (2) informatics tools that facilitate storage, retrieval, processing, and managing the datasets; and (3) detailed data documentation. All data are linked by a unique identifier so that data elements can be rolled up to the individual person-level.

KeyPublications

Fang, M. C., Fan, D., Sung, S. H., Witt, D. M., Schmelzer, J. R., Steinhubl, S. R., ... & Go, A. S. (2017). Validity of Using Inpatient and Outpatient Administrative Codes to Identify Acute Venous Thromboembolism: The CVRN VTE Study.Medical care,55(12), e137-e143.

Fang, M. C., Fan, D., Witt, D. M., Schmelzer, J. R., Yale, S. H., Steinhubl, S. R., ... & Go, A. S. (2013). The association of warfarin control with pulmonary embolism mortality: the CVRN VTE study.

Meyer, M. R., Witt, D. M., Delate, T., Johnson, S. G., Fang, M., Go, A., & Clark, N. P. (2015). Thrombophilia testing patterns amongst patients with acute venous thromboembolism.Thrombosis research,136(6), 1160-1164.



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